NEWCASTLE, England -Iksuda Therapeutics (Iksuda), the next-generation Antibody Drug Conjugate (ADC) company, today announced it has signed a licensing agreement with Femtogenix Limited (FGX), the next-generation ADC payload company. As part of this agreement, Iksuda will use FGX’s sequence-selective DNA-interactive payload molecules to progress its lead ADC towards the clinic, with the aim of targeting difficult-to-treat solid tumours.
Dr Dave Simpson, Chief Executive Officer, Iksuda, said: “This agreement is an exciting progression of our ADC pipeline as it maximises potential for the greatest anti-cancer impact and enhanced therapeutic index, further underpinning our ambition to advance multiple ADCs to the clinic and treat the broadest patient population possible.”
Dr Chris Keightley, Chief Executive Officer, Femtogenix, said: “We are pleased to be working with Iksuda to further validate the clinical potential of our payloads, which should provide improved efficacy and safety in comparison to those currently in the clinic. We have developed a wide range of easily conjugated payloads with novel mechanisms of action and potency levels, and these are available for licensing. In particular, we are developing payloads that can recognise and bind to transcription factor recognition site profiles within the genome. Such profiles are characteristic of specific tumour types, and this allows FGX to develop payloads with reduced toxicity and enhanced target specificity.”